Defect-rich Porous Two-Dimensional Copper-Cobalt Oxide Nanozyme with Photothermal Performance and Enhanced Catalytic Activity for Antibacterial Therapy and Wound Healing

Two-dimensional (2D) materials- based nanozyme are regarded as promising wide-spectrum antibacterial nanoagents due to large surface area and excellent photophysical properties. However, the antibacterial efficacies are still restricted by their low catalytic activity and weak attachment with bacteria. Herein, we report a 2D copper-cobalt oxide nanozyme with porous surfaces and rich defects. The defect-rich porous 2D nanozyme provides abundant highly active sites and vacancy defects, thus exhibiting high peroxidase-mimicking activity, which further enhanced by NIR irradiation, as well as leading to synergistic antibacterial performance with 99