CAMSAP3 negatively regulates lung cancer cell invasion and angiogenesis through nucleolin/HIF-1α mRNA complex stabilization

Suthasinee Seephan,So-Ichiro Sasaki,Onsurang Wattanathamsan,Natsaranyatron Singharajkomron,Ka He,Sisca Ucche,Sakkarin Kungsukool,Supinda Petchjorm,Naphat Chantaravisoot,Piriya Wongkongkathep,Yoshihiro Hayakawa,Varisa Pongrakhananon

LIFE SCIENCES（2023）

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摘要

•Low CAMSAP3 level was strongly relevant with a poor prognosis in lung adenocarcinoma.•CAMSAP3 knockout promotes lung cancer cell invasion and angiogenesis.•CAMSAP3 negatively regulates hif-1α mRNA stability.•Nucleolin-1 is necessary for CAMSAP3-modulating hif-1α mRNA.

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关键词

CAMSAP3,ECM,HIF-1α,HRE,HUVEC,OS,LC3,LUAD,LUSC,KIF3A,MAP4,MMP,NCL,NSCLC,STMN,VEGFA

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