Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000-2022 in Northeastern Italy: Implication for Using p16 INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis.

Paolo Boscolo-Rizzo,Jerry Polesel,Annarosa Del Mistro,Elisabetta Fratta,Chiara Lazzarin,Anna Menegaldo,Valentina Lupato,Giuseppe Fanetti,Fabrizio Zanconati,Maria Guido,Vittorio Giacomarra,Enzo Emanuelli,Margherita Tofanelli,Giancarlo Tirelli

CANCERS（2023）

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摘要

The prevalence of HPV-driven OPSCC continued to increase, even in the most recent period. When using p16 overexpression as a surrogate marker of transforming HPV infection, each institution should consider the subsite-specific prevalence rates of HPV-driven OPSCC as these significantly impact on its positive predictive value.

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关键词

biomarker,epidemiology,head and neck cancer,human papillomavirus,oropharyngeal cancer,p16(INK4a),prevalence,squamous cell carcinoma

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