Carrier-free quercetin nanomedicine blocks NLRP3 deubiquitination and TXNIP recruitment for Parkinson’s disease therapy

Dongju Zhao,Chao Tian,Meng Cheng,Fan Yang,Chunxiao Tian,Yining Liu,Ziyao Chen,Gaoju Pang,Hui Shen,Jin Chang,Yan Dou

CHEMICAL ENGINEERING JOURNAL（2023）

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摘要

•Carrier-free nanomedicine NanoQC is firstly developed by QC self-assembled with PEG.•NanoQC suppresses the deubiquitination of NLRP3 and its interaction with TXNIP.•NanoQC mitigates inflammasome-mediated Parkinson’s neurodegeneration.•NanoQC improves nigral dopaminergic neuronal excitability in PD mice.•NanoQC inhibits the upstream mechanisms of NLRP3 inflammasome assembly against PD.

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关键词

Carrier-free nanomedicine,NLRP3 deubiquitination,Inflammasome assembly,Parkinson’s disease,Neuronal excitability

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