FUNDC1: a key mediator of adenosine A2BR activation-induced inhibition of cardiac mitophagy under ischemia/reperfusion conditions.

Yanyi Tian, Haize Ge,Xiyun Bian,Yao Wang, Yuezhao Lai, Yunqi Wang,Yanwen Bai, Xi Zhang,Jingman Xu,Wei Tian

Cardiovascular diagnosis and therapy（2023）

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摘要

Adenosine A2BR activation may inhibit myocardial mitophagy by downregulating expression of the mitochondrial FUNDC1 by activating Src tyrosine kinase under I/R conditions and could increase the interaction between Src tyrosine kinase and FUNDC1.

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关键词

Adenosine A2B receptor,Src tyrosine kinase,FUNDC1

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