2022-RA-1452-ESGO The prognosis of patients with endometrial cancer is affected by obesity?

Introduction/BackgroundEndometrial carcinoma are divided, based on their histopathological characteristics, into Type I and Type II carcinoma.Type I tumors are mostly endometrioid carcinomas, represent up to ∼80% of endometrial cancers, and are generally associated with endometrial hyperplasia. Type II tumors are more often serous papillary, clear cell, or squamous carcinomas, and generally develop from atrophic endometrial tissue in older women. There is some evidence that endocrine and nutritional lifestyle factors, including obesity, affect the risk of type I but not of type II tumorsMethodologyThe data of 64 consecutive women with endometrial cancer stage FIGO III and IV that presented on out tumor board were retrospectively reviewed. Median age was 64 years, the youngest patient had 34 and the oldest 77 years. In FIGO stage III 56% of patients were diagnosed and 44% of patients in the FIGO stage IV. The majority of the patients in this study were found to have endometrioid histology subtype (41/62, 66.1%). However, the non-endometrioid histologic subtypes were well presented in our population (serous papillar 12/62, 19.3%, and clear cell 9/62,14.5%). Median BMI was 25, BMI underweight 11%, BMI normal 39%, BMI owerweight 50%.ResultsThe most overweight patient was in endometroid histology group, with median BMI of 27.16. The median BMI in non-endometroid histologic subtypes was around 22. In the endometroid histology group most of the patient were obese, 58.54%, underweight was 12% of patients and 29% of patient had normal BMI. In serous papillar subgroup 25% were obese and in clear cell group 35%.ConclusionPatients with endometroid histology had a better prognosis, and were more likely to be overweight.