5 Synthesis of N-containing heterocycles in water

An organic reaction with water as a medium has numerous benefits, like improvement in reactivities and selectivities, simple workup techniques, possibility of recycling the catalyst with milder reaction conditions and eco-friendly synthesis. Further, exploring of water as a reaction medium gives rise to unusual reactivities and selectivities, supplementing the organic chemist’s necessity for reaction media. This review focus on the use of water for the synthesis of Nitrogen-containing heterocycles covering from 2011 to 2021.