TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

Jiecheng Zheng,Dali Zhu,Lin Ling Gan,Zongjie Gan,Zhangyou Yang,Huali Chen, Wei Wang

Synthesis（2022）

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摘要

AbstractA metal-free and facile synthesis of substituted 2-acyloxazole derivatives from α-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.

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