An Unexpected Isomerisation of Isoquinuclidines

SSRN Electronic Journal(2023)

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摘要
The Diels-Alder reaction of three chiral dihydro-2H-[2,3-a]oxazolopyridines with N-methylmaleimide afforded the corresponding chiral cycloadducts as diastereomeric mixtures. In the presence of a solvent, some of the originally formed adducts underwent isomerisation to new isoquinuclidines.
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关键词
1, 2-dihydropyridines, chiral isoquinuclidines, isomerisation
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