Opposite Regulation of Homer Signal at the NMJ Postsynaptic Micro Domain between Slow- and Fast-Twitch Muscles in an Experimentally Induced Autoimmune Myasthenia Gravis (EAMG) Mouse Model.

Martin Schubert,Andreas Pelz,Gabor Trautmann,Katharina Block,Sandra Furlan,Martina Gutsmann,Siegfried Kohler,Pompeo Volpe,Dieter Blottner,Andreas Meisel,Michele Salanova

International Journal of Molecular Sciences（2022）

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摘要

Accelerated postsynaptic remodelling and disturbance of neuromuscular transmission are common features of autoimmune neurodegenerative diseases. Homer protein isoform expression, crosslinking activity and neuromuscular subcellular localisation are studied in mouse hind limb muscles of an experimentally induced autoimmune model of Myasthenia Gravis (EAMG) and correlated to motor end plate integrity. SoleusSOLextensor digitorum longusEDLgastrocnemiusGASEDLSOLSOLEDLGASSOLSOL

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关键词

skeletal muscle,Homer isoform expression,NMJ adaptation,Myasthenia Gravis

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