Effect of extracted rice protein hydrolysate on high-fat diet induced obesity in mice

We investigated the effect of extracted rice protein hydrolysate (ERP), a byproduct of low -protein rice, for use as a therapeutic diet for kidney disease patients. The ERP was composed mostly of peptides and free amino acids. Administering ERP inhibited the body mass compared to obese model mice fed a high -fat diet. ERP administration also significantly increased and decreased fecal triglycerides and epididymal adipose tissue weight, respectively. Blood alanine aminotransferase levels decreased, indicating that hepatic inflammation was reduced. Also, a decrease in ceramide synthase 6, which is related to insulin resistance, was observed. Since ERP was composed mostly of peptides and free amino acids, we hypothesize that the observed effects were due to peptides and/or free amino acids. Based on the findings, ERP is a very useful anti -obesity food additive.