Low non-lesional filaggrin mediates longitudinal Staphylococcus aureus skin colonization, leading to worse atopic dermatitis clinical outcomes in the MPAACH cohort

Arya Dahal,Wan-Chi Chang,Cassandra Almasri,Elisabet Johansson, Makenna Eversole,Veronica Velasquez,Daniel Spagna,Seth Jenkins,Brittany Grashel,Latha Satish,Lisa Martin,Jocelyn Biagini,Gurjit Khurana Hershey

Journal of Allergy and Clinical Immunology（2023）

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摘要

Atopic dermatitis (AD) is frequently characterized by dysbiosis of the skin microflora with increased colonization of Staphylococcus aureus (S. aureus). Persistent S. aureus colonization and its relation to skin barrier function, AD severity, and pathogenesis in early life is poorly understood. We sought to define longitudinal S. aureus colonization phenotypes and AD pathogenesis.

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关键词

atopic dermatitis,worse atopic dermatitis,skin,non-lesional

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