The Bronchodilator Test on FEF 25%-75% in 34 Children and Adolescents with Asthma Sensitized and Non-Sensitized to House Dust Mites

The aim of this case series report was to assess the bronchodilator response on forced expiratory flow at 25%–75% of the vital capacity of children and adolescents with asthma, sensitized and non-sensitized to house dust mites (HDM). A retrospective study was evaluated in the Hospital Municipal Jesus, Rio de Janeiro, Brazil, with 34 participants enrolled as asthma sensitized (n=26) and non-sensitized (n=8) to HDM. In spirometry tests had not obstructions in large airways. Only the FEF 25%-75% values were found reduced in relation to the reference ranges (62% vs. 38%, X2=1.39, P=0.2383) for HDM and non-HDM, respectively. The bronchodilator test with salbutamol was statistically significant in both groups (P<0.005). The measure of bronchodilator response from FEF 25%-75% values was important to evaluate the reversibility of the small airways in children and adolescents with asthma who were sensitized and non-sensitized to HDM.