Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

Dragana Nes̆ić,Marshall C Miller,Zachary T Quinkert,Markus Stein,Brian T Chait,C Erec Stebbins

Nature Structural & Molecular Biology（2009）

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摘要

Helicobacter pylori is a strong risk factor for stomach cancer. The CagA effector protein is translocated into host cells by a type IV secretion system and is a key virulence factor. Its effects are mediated in part through the host polarity kinase PAR1b/MARK2, which CagA binds and inhibits. The crystal structure of a complex between CagA peptide and MARK2 reveals that the CagA peptide mimics targets of this kinase family.

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