Improved efficacy of quizartinib in combination therapy with PI3K inhibition in primary FLT3-ITD AML cells

Salihanur Darici,Heather G. Jørgensen,Xu Huang,Valentina Serafin, Ludovica Antolini,Patrizia Barozzi,Mario Luppi,Fabio Forghieri,Sandra Marmiroli,Manuela Zavatti

Advances in Biological Regulation（2023）

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摘要

Acute myeloid leukemia is a heterogeneous hematopoietic malignancy, characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells, with poor outcomes.

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关键词

Acute myeloid leukemia (AML),FLT3-ITD,PI3K/AKT/mTOR,Quizartinib,BAY-806946,Combination therapy

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