Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study

Kevin K. Wang,Jennifer C. Munoz-Pareja, Lauren A. Lautenslager,J. Adrian Tyndall,Zhihui Yang, Maria R. Kerrigan,Ramon Diaz-Arrastia,Frederick K. Korley,David Okonkwo,Ava M. Puccio,John K. Yue,Sabrina R. Taylor,Pratik Mukherjee,Esther L. Yuh,Nancy R. Temkin,Claudia S. Robertson,Xiaoying Sun,Sonia Jain,Amy J. Markowitz,Geoffrey T. Manley

Advances in Biomarker Sciences and Technology（2023）

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摘要

The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys® levels for identifying TBI patients with structural abnormalities on neuroimaging.

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关键词

TBI,Biomarkers,UCH-L1,Point of care,Mild TBI,NSE

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