circCUL1 promotes autophagy in trophoblast cells via the miR-30e-ATG7/14 and ANXA1/PI3K/AKT pathways

Abstract Background Fetal growth restriction seriously affects the health of newborns. However, the cause of FGR is unclear. Circular RNAs (CircRNAs) are a novel type of endogenous noncoding RNAs that regulate target gene expression by interacting with microRNA (miRNA) .The present research was major in investigating the regulation association among circCUL1, miR-30e, ATG7/14 and MAPK1 in FGR, and we explored the mechanism underlying pathogenesis of FGR Results circCUL1 promotes autophagy in placental trophoblast cells. Mechanism studies have found that circCUL1 regulates trophoblast autophagy through the miR-30e-ATG7/14 and ANXA1/PI3K/AKT pathways. We also observed that knocking out circCUL1 promoted mouse development. Conclusions our research suggested that circCUL1 may be involved in the pathogenesis of FGR. circCUL1 may be a potential diagnostic marker and therapeutic target of FGR.