Validation Of Kyoto Classification Of Gastritis On Magnetic Controlled Capsule Endoscope

Abstract Backgrounds: Previous studies showed that Kyoto classification of gastritis could accurately predict H. pylori infection status on conventional gastroscope. The aim of this study was to testify whether Kyoto classification of gastritis applies well on magnetic controlled capsule endoscopy (MCCE).Methods: This study included two phases, both of which were basically a group of diagnostic tests. In phase one which included 35 participants who had undergone both conventional gastroscope and MCCE, we testified whether major findings documented in Kyoto classification of gastritis could be well recognized on MCCE. Then, in phase two, we consecutively recruited 227 participants who had under gone both MCCE and urea breath test (UBT). The diagnosis of H. pylori infection status was independently made by 2 physicians who were blinded to UBT results and well versed in Kyoto classification of gastritis after reviewing MCCE images. Results: In phase one, all of the 10 findings selected from Kyoto classification of gastritis could be well recognized on MCCE, when findings on conventional gastroscope were used as the gold standard, the overall diagnostic accuracy, sensitivity and specificity were 96.6%, 84,7% and 100.0% respectively. In phase two, MCCE’s overall diagnostic accuracy on H. pylori infection status was 80.2%. The sensitivity, specificity and diagnostic odds ratio (DOR) for current-infection were 89.4%, 90.1% and 77.1 respectively. Major specific findings were mucosal swelling and spotty redness for current infection, regular arrangement of collecting venules (RAC), streak redness, fundic gland polyp (FGP) for non-infection, and map redness for past-infection.Conclusions: Kyoto classification of gastritis applied well on MCCE. H. pylori infection status could be accurately assessed on MCCE.