Combined Effects of Dyslipidemia and Obesity Parameters on The Estimated Glomerular Filtration Rate in a Middle-Aged Population

Abstract BackgroundSome studies have reported that chronic kidney disease (CKD) or the estimated glomerular filtration rate (eGFR) is significantly associated with metabolic-related parameters, such as dyslipidemia and obesity. However, whether eGFR will change under the superposition of multiple specific metabolic indicators remains unclear.MethodsSix hundred forty-six community residents aged 45–60 years without overt renal dysfunction were recruited in this cross-sectional study. eGFR was calculated by measuring serum creatinine. The visceral fat area (VFA) and subcutaneous fat area (SFA) were assessed by magnetic resonance imaging (MRI). The body mass index (BMI) and waist-hip ratio (WHR) were also evaluated. Additionally, we tested the subjects' blood lipid levels to diagnose dyslipidemia.ResultsCompared with the subjects with neither dyslipidemia nor obesity, men with both dyslipidemia and high obesity indices, such as BMI, WHR and VFA, showed a significantly lower mean eGFR; women with dyslipidemia with high WHR, VFA or SFA also showed a significantly lower mean eGFR. With the superposition of dyslipidemia and obesity indices such as BMI and SFA, the eGFR level showed a significant decreasing trend in men; the eGFR level also showed a significant decreasing trend in women but with the superposition of dyslipidemia plus WHR or SFA. Although an independent association between metabolic variables and eGFR was not found except for BMI, some of the combined effects of each variable were related to eGFR decline. Double positivity for dyslipidemia and high obesity indices such as BMI and VFA were significant independent risk factors for eGFR reduction in men. Additionally, double positivity for dyslipidemia and high WHR were significant independent risk factors for eGFR reduction overall.ConclusionsThe combined effect of dyslipidemia and high obesity indices is significantly related to the decline in eGFR. The association is more profound in men.