Development and characterization of an ETV1 rabbit monoclonal antibody for the immunohistochemical detection of ETV1 expression in cancer tissue specimens

Cara Schafer,Denise Young, Harpreet Singh, Rahul Jayakrishnan,Sreedatta Banerjee,Yingjie Song,Albert Dobi,Gyorgy Petrovics,Sudhir Srivastava,Shiv Srivastava,Isabell A. Sesterhenn,Gregory T. Chesnut,Shyh-Han Tan

Journal of Immunological Methods（2023）

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摘要

•Aberrant ETV1 expression occur in many cancers due to gene mutations or fusions.•Lack of ETV1 specific antibodies prevents understanding of its oncogenic function.•Characterization of a rabbit ETV1 mAb we developed highlights its specificity.•IHC detection of ETV1 in prostate cancer tissues showed a unique staining pattern.•Results support a potential use of the mAb for cancer diagnosis and prognosis.

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关键词

ETV1,Rabbit monoclonal antibody,Antibody characterization,Prostate cancer,cancer diagnosis

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