Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness.

Bassem Refaat,Akhmed Aslam,Shakir Idris, Ahmed H Almalki,Mofareh Y Alkhaldi, Hassan A Asiri,Riyad A Almaimani,Abdulrahman Mujalli,Faisal Minshawi, Sara A Alamri,Mona I AlHussain, Badee A Baltow, Mansour H Alqasmi,Ghaiyda T Basfar, Ohoud M Alosaimi,Ibrahim A Muhayya

Frontiers in endocrinology（2023）

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摘要

This study advocates that protein expression of sex steroid receptors in malignant tissues could represent prognostic markers, as well as hormonal therapy could provide an alternative strategy against CRC, and their efficacies could be dependent on gender, clinical stage, and tumor location.

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关键词

testosterone,cell cycle,apoptosis,left-right dichotomy,mifepristone,bicalutamide,estrogen receptor-beta (ER beta),estrogen receptor-alpha (ER alpha)

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