Response Surface Methodology Study of Extended-Time Metformin/glibenclamide Drug Delivery System from Polycaprolactone/polyethylene Glycol Electrospun Nanofibers

Regulated delivery of drugs plays a key role in control and treatment of diabetes type II. The lack of patient compliance is one of the main hurdles of successful regulated drug delivery. Extended release drug delivery systems are one of the best solutions for this problem. Electrospinning is an easy method for production of nanofibers as drug delivery systems capable of being tailored for various release kinetics, including extended release form. Response surface methodology is employed to fine tune input variables, including electrical field intensity, base polymer ratio, and total polymer concentration to study the behavior of output parameters. The study validates the feasibility of using polyethylene glycol (PEG)/polycaprolctone (PCL) nanofibers drug delivery systems as an extended time release medium for metformin and glibenclamide co-delivery. A new drug release model is presented and its parameters indicate the possibility of using drug for at least T_60=60 h with average and sustained release rate of 5.37μg_drug / g_solidh . The system traps as little as 10