Pyrazoles containing organic extracts of Litsea glutinosa (Lour.) C. B. Rob enervate chemical-induced diarrhea in animal models evident in ligand-receptor interaction

•Litsea glutinosa bark extract displayed an excellent anti-diarrheal role in an animal model.•Methanol extract showed the best in anti-diarrheal effect.•Gastrointestinal motility was profoundly reduced by methanol extract.•Restoration of electrolytes and immunoglobulin G were consistent.•Impacts were evident in the computational study of strong ligand-receptor interaction.•Heterocyclic 1-(2-Fluorophenyl)pyrazole-4-carboxylic acid remarkably supported the anti-diarrheal effect.