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Amygdala-HippocampusCoherence is a Biomarker of Predominant Symptom Sets in Patients With Depression

Joshua Cohen,Joline M. Fan,Kristin K. Sellers,Ankit N. Khambhati,Heather E. Dawes,Katherine W. Scangos,Vikram R. Rao,Leo P. Sugrue,Philip A. Starr,Edward F. Chang,Andrew D. Krystal

Biological Psychiatry（2023）

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Abstract
Intracranial electroencephalography (iEEG) performed in patients with epilepsy showed amygdala-hippocampus signal coherence was correlated with mood. This study investigated whether amygdala-hippocampus coherence is predictive of mood in patients with major depressive disorder (MDD), who do not have epilepsy, and the effects of deep brain stimulation on coherence and mood.
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Key words
MajorDepressiveDisorder,Deep Brain Stimulation,Biomarkers,limbic system
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