The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis

Larissa M. Gomes Cassiano,Danilo Bretas de Oliveira,Talitah Michel Sanchez Candiani,Ana Carolina Campi-Azevedo,Olindo Assis Martins-Filho,Erna Geessien Kroon,Markus Kohlhoff,Roney Santos Coimbra

Cytokine（2023）

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摘要

•Acute bacterial or enteroviral meningitis intrathecally activate the KYN pathway.•Pneumococcal meningitis strongly activates the neurotoxic branch of the KYN pathway.•IL-6, TNF-α and IL-10 are not likely to regulate the KYN pathway in meningitis.

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