High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants

Solène Micou,Isabel Forner-Piquer,Noémie Cresto, Tess Zassot, Aurélien Drouard, Marianna Larbi,Matteo E. Mangoni,Etienne Audinat,Chris Jopling,Adèle Faucherre,Nicola Marchi,Angelo G. Torrente

Environmental Technology & Innovation（2023）

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摘要

Environmental contaminants represent a poorly understood ecotoxicological and health risk. Here, we advanced a high-speed optical mapping (OM) technique to non-invasively track voltage dynamics in living zebrafish larvae’s heart and brain and investigate the effects of selected pesticides.

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关键词

Heart rate, Heart depolarization, Brain voltage activity, Pesticide cocktail, Glyphosate, Optical mapping, Exposome

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