Efficacy of different strategies of responsive neurostimulation on seizure control and their association with acute neurophysiological effects in rats

•Only promising targets combined with an appropriate stimulation frequency could efficiently suppress seizures.•High-frequency stimulation of CA1 significantly shortened ongoing seizure duration, which may be related to increased synchronization after stimulation.•Both high-frequency stimulation of the CA1 and low-frequency stimulation of the subiculum could reduce seizure frequency, which may be correlated with the change in power ratio near the theta band.