STING regulates the transformation of the proinflammatory macrophage phenotype by HIF1A into autoimmune myocarditis

Xiumeng Hua,Mengni Bao,Han Mo,Zhe Sun,Mengda Xu,Xiao Chen,Xiuxue Mo,Gang Hu,Menghao Tao,Jiangping Song

International Immunopharmacology（2023）

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摘要

•Sting expression level correlates with Hif1α expression in the acute phase of EAM.•STING expression and ssDNA accumulation in macrophages were observed in human myocarditis.•STING may serve as a potential therapeutic target for autoimmune myocarditis.

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