Dimethyl fumarate possesses antiplatelet and antithrombotic properties

Xiang Chu, Jie Zhang,Yingying Li,Ke Yuan, Xue Wang,Xiang Gui,Yueyue Sun, Chaonan Geng,Wen Ju,Mengdi Xu,Zhenyu Li,Lingyu Zeng,Kailin Xu,Jianlin Qiao

International Immunopharmacology（2023）

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摘要

•Dimethyl fumarate (DMF) dose-dependently inhibits platelet function, hemostasis and arterial/venous thrombosis.•DMF reduces reactive oxygen species production, calcium mobilization and NF-κB/MAPK/AKT signaling.

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关键词

Dimethyl fumarate, Platelets, Thrombosis, Hemostasis, Multiple sclerosis

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