Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance

•Mutations outside the FKS1-HS regions in C. parapsilosis do not confer echinocandin resistance.•Mutations outside the FKS1-HS regions in C. parapsilosis confer high echinocandin tolerance.•Mutations outside the FKS1-HS regions in C. parapsilosis facilitate acquirement of bona fide echinocandin resistance.•Mutations outside the FKS1-HS regions in C. parapsilosis are clinically important, should not be underestimated, and need to be cataloged.