The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.

Jingyi Li, Ming Zhang, Yiying Pei,Qifang Yang,Lihua Zheng,Guannan Wang,Ying Sun,Wei Yang,Lei Liu

Journal of Ethnopharmacology（2023）

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摘要

These findings indicate that ALK of Sophora alopecuroides L. can effectively improve the depressive phenotype of mice, possibly by promoting the expression of BDNF in prefrontal cortex, activating the downstream AKT/mTOR signal pathway, and ultimately enhancing neuronal dendritic complexity.

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关键词

Antidepressant,Sophora Alopecuroides L.,Alkaloid,BDNF

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