Uncovering Mechanisms of Cutaneous Denervation in Painful Diabetic Neuropathy Using an Unbiased Single-Cell Transcriptional Approach

group) and the effects were blocked by a pan-alpha1 ADR antagonist.These results suggest 1) tumor-induced sensory and sympathetic nerve injury may underly oral cancer pain, and 2) sensory and sympathetic ADR plasticity allows for NE released by SCG axons in the TG to act on alpha1-ADRs on nociceptors contributing to sympathetically-maintained pain.NIH NIDCR R01DE030892.T a g g e d E n d