Associations and One-year Trends of Frailty, Cognition, Disability, and Quality of Life in Individuals with Chronic Limb-threatening Ischemia
JOURNAL OF VASCULAR SURGERY(2023)
摘要
Abstract Introduction This study aimed to describe the associations of frailty with cognition, disability, and quality of life (QoL) among individuals with chronic limb-threatening ischaemia (CLTI) over one-year following intervention. Methods Single-centre prospective cohort study. Patients aged ≥65 with CLTI and a planned intervention between May 2019 and May 2021 were eligible for inclusion. Patients underwent frailty, cognitive function, disability and QoL assessments before their procedure. Delirium screening was performed at 24- and 72-hours post-operatively. Frailty, disability and QoL assessments were repeated at three- and 12-months. Results Ninety-nine patients completed baseline assessments, of whom 45 (45%) were classified as frail by the Edmonton frail scale. Frailty was strongly associated with higher prevalence of cognitive impairment (52% vs 17%; p<.001). Eighty-seven patients underwent a procedure. Ten (11%) developed POD, of whom 8 had frailty (p=.003). Cognitive impairment (OR 8.52; 95%CI 1.12, 64.67; p=.038) was independently associated with POD. Frailty was associated with worse vascular quality of life questionnaire (VascuQoL) (p=.001) and EQ-5D-5L scores (p<.001) at all timepoints, however both those with and without frailty had modest improvement in VascuQoL and EQ-5D-5L scores at 12-months (p=.001). Barthel index (disability) scores were lower for those with frailty (p<.001) and decreased slightly over 12-months for both groups (p=.007). Five patients (12%) transitioned from frailty to non-frailty at 12-months (clinical frailty scale), however 10 patients (23%) transitioned from non-frailty to frailty. Conclusion CLTI patients with frailty have worse cognition, QoL and disability. Overall, individuals with CLTI demonstrate progression in frailty and disability at one-year post-intervention.
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