Chelerythrine inhibits HSV-1 infection by suppressing virus binding to the cells

Ziwei Hu,Chaowei Zhang,Jianfeng Zhong,Hao Hu,Chenyang Li,Yunshi Zhao,Lu Wang,Liang Ye, Cong Yan,Mingzhong Wang,Qinchang Zhu,Bo Wen,Longxia He,Muhammad Shahid Riaz Rajoka,Xun Song,Zhendan He

Pharmacological Research - Modern Chinese Medicine（2023）

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摘要

Chelerythrine (CHE) inhibits HSV-1 infection by suppressing virus binding to the cells.CHE inhibits HSV-1 ICP0 expression in the immediate early stage of infection.CHE might interact with gB and/or gD, resulting in conformational changes to interfere virus-cell fusion.

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关键词

Herpes simplex virus type 1,Chelerythrine,Antiviral,Glycoprotein B,Glycoprotein D

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