Leucine zipper protein 1 prevents doxorubicin-induced cardiotoxicity in mice

Di Fan,Zhili Jin,Jianlei Cao,Yi Li,Tao He,Wei Zhang,Li Peng,Huixia Liu,Xiaoyan Wu,Ming Chen,Yongzhen Fan,Bo He,Wenxi Yu,Hairong Wang,Xiaorong Hu,Zhibing Lu

Redox Biology（2023）

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摘要

LUZP1 attenuates DOX-induced inflammation, oxidative damage, cell apoptosis and ventricular impairment through regulating AMPK pathway, and gene therapy targeting LUZP1 may provide novel therapeutic approached to treat DOX-induced cardiotoxicity.

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关键词

AMPK, Doxorubicin, Inflammation, LUZP1, Oxidative stress

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