Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.

Liu Yang,Hao Wu,Congcong Luo,Yang Zhao,Rongbo Dai,Zhiqing Li,Xu Zhang,Ze Gong,Zeyu Cai,Yicong Shen,Fang Yu,Wei Li,Hongmei Zhao,Tao Zhang,Junming Zhu,Yi Fu,Jing Wang,Wei Kong

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid-lowering drug may represent a promising therapeutic approach for TAAD.

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关键词

aortic aneurysm, thoracic, aortic dissection, allopurinol, hyperuricemia, inflammation, receptors, IgG

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