Dysfunctional Adipose Tissue and Skeletal Muscle Insulin Resistance: Cause and Effect or Two Sides of the Same Coin?

ObesityVolume 31, Issue 5 p. 1185-1187 COMMENTARY Dysfunctional adipose tissue and skeletal muscle insulin resistance: Cause and effect or two sides of the same coin? This article relates to: Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin Michael W. Schleh, Benjamin J. Ryan, Cheehoon Ahn, Alison C. Ludzki, Pallavi Varshney, Jenna B. Gillen, Douglas W. Van Pelt, Lisa M. Pitchford, Suzette M. Howton, Thomas Rode, Thomas L. Chenevert, Scott L. Hummel, Charles F. Burant, Jeffrey F. Horowitz, Volume 31Issue 5Obesity pages: 1347-1361 First Published online: March 29, 2023 Max C. Petersen, Corresponding Author Max C. Petersen [email protected] orcid.org/0000-0001-8646-2377 Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, USA Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA Correspondence Max C. Petersen, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, MSC 8127-21-05, 660 S Euclid Ave, St. Louis, MO 63110, USA. Email: [email protected]Search for more papers by this authorBettina Mittendorfer, Bettina Mittendorfer orcid.org/0000-0003-0049-2677 Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USASearch for more papers by this author Max C. Petersen, Corresponding Author Max C. Petersen [email protected] orcid.org/0000-0001-8646-2377 Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, USA Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA Correspondence Max C. Petersen, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, MSC 8127-21-05, 660 S Euclid Ave, St. Louis, MO 63110, USA. Email: [email protected]Search for more papers by this authorBettina Mittendorfer, Bettina Mittendorfer orcid.org/0000-0003-0049-2677 Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USASearch for more papers by this author First published: 26 April 2023 https://doi.org/10.1002/oby.23750 See accompanying article, pg. 1347. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. CONFLICT OF INTEREST STATEMENT The authors declared no conflict of interest. REFERENCES 1Smith GI, Mittendorfer B, Klein S. Metabolically healthy obesity: facts and fantasies. J Clin Invest. 2019; 129: 3978-3989. 10.1172/JCI129186 PubMedWeb of Science®Google Scholar 2Klein S, Gastaldelli A, Yki-Jarvinen H, Scherer PE. Why does obesity cause diabetes? Cell Metab. 2022; 34: 11-20. 10.1016/j.cmet.2021.12.012 CASPubMedWeb of Science®Google Scholar 3Schleh MWR, Ahn C, Ludzki AC, et al. Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin. Obesity. 2023; 31: 1347-1361. doi:10.1002/oby.23734 10.1002/oby.23734 CASPubMedWeb of Science®Google Scholar 4Koh HE, van Vliet S, Pietka TA, et al. Subcutaneous adipose tissue metabolic function and insulin sensitivity in people with obesity. Diabetes. 2021; 70: 2225-2236. 10.2337/db21-0160 CASPubMedWeb of Science®Google Scholar 5Kleiboeker B, Lodhi IJ. Peroxisomal regulation of energy homeostasis: effect on obesity and related metabolic disorders. Mol Metab. 2022; 65:101577. doi:10.1016/j.molmet.2022.101577 10.1016/j.molmet.2022.101577 CASPubMedWeb of Science®Google Scholar 6Espinosa De Ycaza AE, Sondergaard E, Jensen MD. Response to comment on Espinosa De Ycaza et al. Adipose tissue inflammation is not related to adipose insulin resistance in humans. Diabetes 2022;71:381–393. Diabetes. 2022; 71: e8-e9. doi:10.2337/dbi22-0005 10.2337/dbi22-0005 PubMedWeb of Science®Google Scholar Volume31, Issue5May 2023Pages 1185-1187 ReferencesRelatedInformation