Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease.

Luigi Ferrucci,Julián Candia,Ceereena Ubaida-Mohien,Alexey Lyaskov,Nirad Banskota,Christiaan Leeuwenburgh,Stephanie Wohlgemuth,Jack M Guralnik,Mary Kaileh,Dongxue Zhang,Robert Sufit,Supriyo De,Myriam Gorospe,Rachel Munk,Charlotte A Peterson,Mary M McDermott

Circulation research（2023）

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摘要

In PAD muscle, hypoxia induces accumulation of mitochondria respiratory proteins, reduced activity of rate-limiting glycolytic enzymes, and an enhanced integrated stress response that modulates protein translation. These mechanisms may serve as targets for disease modification.

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关键词

gastrocnemius muscle,peripheral artery disease,proteomic

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