Epidermal Growth Factor Receptor Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage in Mice.

Fumi Nakano,Hideki Kanamaru,Fumihiro Kawakita,Lei Liu,Yoshinari Nakatsuka,Hirofumi Nishikawa,Takeshi Okada,Hidenori Suzuki

Stroke（2023）

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摘要

Activated EGFR, nuclear-NIK, and NFκB expressions were observed in cortical degenerating neurons after SAH, and were decreased by administration of AG1478, associated with suppression of TUNEL- and cleaved caspase-3-positive neurons. EGFR/NIK/NFκB pathway is suggested to be involved in neuronal apoptosis after SAH in mice.

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关键词

subarachnoid hemorrhage,epidermal growth factor receptor,epidermal growth factor,apoptosis,growth factor

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