Longitudinal stability of progression-related microglial activity during teriflunomide treatment in patients with multiple sclerosis.
European journal of neurology(2023)
摘要
Compared to controls, treated patients exhibited modest signs of diffuse innate immune cell activity, which was unaltered during follow-up. Lesion-associated smoldering inflammation was negligible at both timepoints. To our knowledge, this is the first study applying both TSPO-PET and QSM-MRI to longitudinally evaluate smoldering inflammation.
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关键词
magnetic resonance imaging, multiple sclerosis, positron emission tomography, quantitative susceptibility mapping, teriflunomide
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