Longitudinal stability of progression-related microglial activity during teriflunomide treatment in patients with multiple sclerosis.

European journal of neurology(2023)

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摘要
Compared to controls, treated patients exhibited modest signs of diffuse innate immune cell activity, which was unaltered during follow-up. Lesion-associated smoldering inflammation was negligible at both timepoints. To our knowledge, this is the first study applying both TSPO-PET and QSM-MRI to longitudinally evaluate smoldering inflammation.
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magnetic resonance imaging, multiple sclerosis, positron emission tomography, quantitative susceptibility mapping, teriflunomide
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