Diet, gut microbiome and their end-metabolites associate with acute pancreatitis risk.

Cemal Yazici,Sarang Thaker,Karla K Castellanos,Haya Al Rashdan,Yongchao Huang, Paya Sarraf,Brian Boulay,Paul Grippo,H Rex Gaskins,Kirstie K Danielson,Georgios I Papachristou,Lisa Tussing-Humphreys,Yang Dai,Ece R Mutlu,Brian T Layden

Clinical and translational gastroenterology（2023）

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摘要

AP patients have decreased beneficial nutrient intake and gut microbiome diversity. Increased abundance of H2S producing genera in the AP, SCFA producing genera in the control group, and predictive ability of ML model to distinguish AP patients indicates that diet, gut microbiota and their end-metabolites play a key role in AP.

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