Reduced immunogenicity of a live Salmonella enterica serovar Typhimurium vaccine in aged mice.

Jessica C Allen,Franklin R Toapanta,Scott M Baliban,Marcelo B Sztein,Sharon M Tennant

Frontiers in immunology（2023）

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摘要

These data suggest that our candidate live attenuated Typhimurium vaccine, CVD 1926, may not be sufficiently protective or immunogenic in older humans and that mucosal responses to live-attenuated vaccines decrease with increasing age.

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immunogenicity,aged mice

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