SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.

Yi Li,Niklas Dörmann,Björn Brinschwitz,Melanie Kny, Elisa Martin,Kirsten Bartels,Ning Li,Priyanka Voori Giri,Stefan Schwanz,Michael Boschmann,Susanne Hille,Britta Fielitz,Tobias Wollersheim,Julius Grunow,Stephan B Felix,Steffen Weber-Carstens,Friedrich C Luft,Oliver J Müller,Jens Fielitz

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

Inflammatory cytokines via their respective signalling pathways cause an increase in SPSB1 expression in myocytes and attenuate myogenic differentiation. SPSB1-mediated inhibition of TβRII-Akt-Myogenin signalling and protein synthesis contributes to a disturbed myocyte homeostasis and myogenic differentiation that occurs during inflammation.

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