Free light chains as a reliable biomarker of intrathecal synthesis in the diagnosis of CNS inflammatory diseases.

Laura Michetti,Francesca Maffina,Rudi Ravasio,Valeria Barcella,Marta Radaelli,Lorenzo Chiudinelli,Maria Sessa,Maria Grazia Alessio

Journal of neuroimmunology（2023）

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摘要

FLC indices are biomarkers of intrathecal Immunoglobulin synthesis and central nervous system (CNS) inflammation. kFLC index can discriminate between MS and other CNS inflammatory disorders, while λFLC index is less informative for MS but can play a role to support the diagnosis of other inflammatory CNS disorders.

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关键词

Diagnostic performance, Multiple sclerosis, FLC index, Oligoclonal bands, IgG-index

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