Association of RANKL and EGFR gene expression with bone metastases in patients with metastatic non-small cell lung cancer.

Anita J W M Brouns,Lizza E L Hendriks, Iris J Robbesom-van den Berge,Annemariek J H M Driessen,Guido M J M Roemen, Britt L J van Herpen, Zoë Dekkers, Bas Heitzer,Daphne J G Leunissen,Laura Moonen, Ragnar Lunde,Marcel Westenend,Marjolein van Driel,Ernst-Jan M Speel,Anne-Marie C Dingemans

Frontiers in oncology（2023）

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摘要

Increased RANKL gene expression and RANKL: OPG ratio, but not EGFR expression, was associated with presence of bone metastases. Additionally, an increased RANKL: OPG gene ratio was associated with a higher incidence of bone metastases development.

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关键词

egfr gene expression,bone metastases,lung cancer,non-small

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