The top 10 research priorities for inflammatory bowel disease in children and young adults: results of a James Lind Alliance Priority Setting Partnership

Jasmijn Z Jagt,Patrick F van Rheenen, Sophia M A Thoma, Jonathan Gower,Pamela B Reimering-Hartgerink,Heidi J H L van der Wielen, Esther J van Steenbergen, Anne-Marije Goutbeek,Elisabeth M van Dijk-Lokkart,Stijn Vlietstra,Dana Reinders, Yanniek den Otter,Isabella Schoonderwoert,Bas Schoonderwoert,Hannie Schoonderwoert,Germa van der Weide, Simone van Harten,Kees Mouthaan,Marc A Benninga,Nanne K H de Boer

The lancet. Gastroenterology & hepatology（2023）

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摘要

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic idiopathic disorder characterised by relapsing and remitting inflammation of the gastrointestinal tract. 1 Baumgart DC Carding SR Inflammatory bowel disease: cause and immunobiology. Lancet. 2007; 369: 1627-1640 Summary Full Text Full Text PDF PubMed Scopus (1503) Google Scholar Recent large population-based registry studies in Europe showed that around 8% of patients with IBD are diagnosed before age 18 years. 2 Ghione S Sarter H Fumery M et al. Dramatic increase in incidence of ulcerative colitis and Crohn's disease (1988–2011): a population-based study of French adolescents. Am J Gastroenterol. 2018; 113: 265-272 Crossref PubMed Scopus (107) Google Scholar , 3 Dorn-Rasmussen M Lo B Zhao M et al. The incidence and prevalence of paediatric- and adult-onset inflammatory bowel disease in Denmark during a 37-year period: a nationwide cohort study (1980–2017). J Crohn's Colitis. 2023; 17: 259-268 Crossref PubMed Scopus (3) Google Scholar Over the past three decades, IBD has become a global disease with rising incidence rates, especially in low-income and middle-income countries in Asia, South America, and Africa. 4 Ng SC Shi HY Hamidi N et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017; 390: 2769-2778 Summary Full Text Full Text PDF PubMed Scopus (2905) Google Scholar In the paediatric population, the prevalence of IBD continues to rise worldwide, with the highest prevalence rates reported in Europe, ranging from 31 cases per 100 000 people to 75 cases per 100 000 people. 5 Kuenzig ME Fung SG Marderfeld L et al. Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: systematic review. Gastroenterology. 2022; 162: 1147-1159 Summary Full Text Full Text PDF PubMed Scopus (94) Google Scholar

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inflammatory bowel disease,research priorities

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