Dendritic cell therapy augments antitumor immunity triggered by CDK4/6 inhibition and immune checkpoint blockade by unleashing systemic CD4 T-cell responses.

Amrendra Kumar,Vijay Ramani,Vijaya Bharti,Daniel de Lima Bellan,Nabil Saleh,Roman Uzhachenko,Chengli Shen,Carlos Arteaga,Ann Richmond,Sangeetha M Reddy,Anna Vilgelm

Journal for immunotherapy of cancer（2023）

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摘要

Our findings suggest that CDK4/6i-mediated DC suppression limits CD4 T-cell responses essential for the sustained activity of CD8 T cells and tumor inhibition. Furthermore, they imply that restoring DC-CD4 T-cell crosstalk via DC transfer enables effective breast cancer immunity in response to CDK4/6i and ICB treatment.

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关键词

dendritic cell therapy,immune checkpoint blockade,antitumor immunity,t-cell

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