Embryonic inhibition of colony-stimulating factor 1 receptor impacts craniofacial morphogenesis.

Ashina Nagra,Motoki Katsube, Wade Gao,Jessica M Rosin,Siddharth R Vora

Orthodontics & craniofacial research（2023）

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摘要

Embryonic inhibition of CSF1R impacts postnatal craniofacial morphogenesis, with significant influences on the mandibular and cranioskeletal size and shape. These data indicate that CSF1R plays a role in early cranio-skeletal patterning, likely through osteoclast depletion.

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关键词

craniofacial morphogenesis, CSF1R, embryonic development, geometric morphometrics, osteoclasts

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