Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease.

Suzanne Cole, Avneet Manghera,Lachrissa Burns, Janine Barrett,Nicole Yager,Hefin Rhys,Andrew Skelton,John Cole,Carl S Goodyear, Meryn Griffiths,Dominique Baeten, Marta Bertolini,Stevan Shaw,Hussein Al-Mossawi,Asher Maroof

The Journal of allergy and clinical immunology（2023）

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摘要

Our data suggest there are key differences in the regulation of IL-17A and IL-17F in psoriatic disease, leading to distinct inflammatory cell populations. As such, we propose that both IL-17A and IL-17F neutralization may be required to maximally inhibit IL-17-driven pathology.

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关键词

IL-17A,IL-17F,STAT5,bimekizumab,psoriasis,psoriatic arthritis,autoimmunity,inflammation

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