Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia.

Feng Li,Bowen Niu,Lingling Liu,Mengmin Zhu,Hua Yang,Boyin Qin,Xiuhua Peng,Lixiang Chen,Chunhua Xu,Xiaohui Zhou

Animal models and experimental medicine（2023）

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摘要

These humanized mice will be an invaluable mouse model to resolve the pathological mechanism of S. aureus pneumonia and study what role DP molecule plays in S. aureus infection.

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关键词

HLA DP401, HLA-DRA, humanized mice, MHC II, Staphylococcus aureus pneumonia, transgene

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